Abstract: Acute attack of primary angle-closure disease is characterized by acute closure of anterior chamber angle and a dramatic increase in intraocular pressure. However, a variety of patients with ocular or systemic diseases can lead to the similar symptoms and signs, which represent as secondary acute angle-closure disease, such as zonlar dysfunction, intraocular inflammation or tumor causing angle closure. Therefore misdiagnosis should be alerted. Detailed history taking, careful ocular checking and auxiliary examinations should be made for correct diagnosis and appropriate treatment. (Ophthalmol CHN, 2015, 24: 76-78)